Han Lab

Dr. Jian HanJian Han, M.D., Ph.D. (read bio)
Faculty Investigator


Research interests

  • Developing integrated solutions for molecular differential diagnosis. Biochemical reactions, such as the polymerase chain reaction, are like software in the IT industry, they require tailor-made hardware to become more functional. Dr. Han is developing an integrated technology platform that allows multiplexmolecular differential diagnoses carried out in a fashion that is high throughput, semi-quantitative, automatic, and with a closed system.
  • Applying the multiplex PCR technology, Dr. Han is developing a method to study interactions between our immune system and the environment.

Information for the scientific community on Dr.Han's latest project can be found by going to the personal webpage The Repertoire 10K (R10K) Project

Recap of Rocket City Science Cafe featuring Jian Han, M.D., Ph.D.

News Outlet: 
The Huntsville Times, al.com
Date published: 
September 3, 2013
HUNTSVILLE, Alabama - Doctors are probably asking the wrong question when they wonder "what caused your disease," human genetics researcher and entrepreneur Dr. Jian Han said Tuesday night. According to Han, a better question might be, "What is your immune system doing today?"
Han, a research scientist at theHudsonAlpha Institute for Biotechnology and founder of several private companies, explained his theory of disease diagnosis to scientifically curious locals attending the second monthly meeting of Huntsville's new Rocket City Science Café.

HudsonAlpha initiates study to examine disease risk

R10K will include 10,000 patient samples
HUNTSVILLE, Ala. -Dr. Jian Han, faculty investigator at the HudsonAlpha Institute for Biotechnology, has announced a major project that aims to help identify risks for 100 human diseases.  The Repertoire 10K Project will sequence the immune repertoire of 10,000 individuals with specific disease histories and then seek to identify T and B cell receptor sequences associated with these specific diseases.

R10K, Jian Han featured in Birmingham publication

News Outlet: 
Birmingham Medical News
Date published: 
July 19, 2013
“When something goes wrong, the immune system knows. It diagnoses the problem and tries to treat it,” Jian Han, M.D., Ph.D., said. “We want to learn what the immune system can teach us about improving our ability to diagnose diseases, evaluate the prognosis of patients and manage their treatment.”

HudsonAlpha researcher Jian Han, M.D., Ph.D., teams up with UAH researcher to identify invasive plant species

News Outlet: 
Date published: 
April 28, 2013

HUNTSVILLE, Ala. — University of Alabama in Huntsville assistant biology professor Dr. Leland Cseke and HudsonAlpha Institute for Biotechnology researcher Dr. Jian Han have joined forces to identify invasive plant species that are sneaking into the United States because they look just like desirable crops or ornamentals.

Co-detection of Pandemic (H1N1) 2009 Virus and Other Respiratory Pathogens

News Outlet: 
Emerging Infectious Disease
Date published: 
December 1, 2010
Download PDF: 

Members of the Han Lab at HudsonAlpha and employees at Diatherix Laboratories were recently published in a paper about the 2009 H1N1 oubreak.

Download the PDF above or access the paper here.

“Most Promising” China Life Science Companies Named at BioBay Investor Forum

News Outlet: 
Date published: 
November 5, 2010

BeiGene LLC and Suzhou KeyBay Biotechnology Inc. Selected by a Panel of VCs and Pharma Executives as Most Likely to Succeed

Tailoring treatment

News Outlet: 
The Huntsville Times R&D Report
Date published: 
September 5, 2010
Download PDF: 

By Wendy Reeves

Award-winning HudsonAlpha researcher's iCubate device shortens pathogen identification time.

Read the full article by opening the attached PDF or by viewing The Huntsville Times R&D Report online.

Researchers turn to immune repertoire sequencing to better understand disease

News Outlet: 
Date published: 
August 31, 2010

By Monica Heger

As next-generation sequencing gains more traction in labs, researchers are increasingly using the technology to understand more complex human systems such as the immune repertoire.

Han's recent findings on the human immune system published in National Academy of Sciences journal

T cell illustrationDr. Jian Han and fellow scientists at the HudsonAlpha Institute for Biotechnology were recently published with the paper—High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets—in the journal Proceedings of the National Academy of Sciences

Download PDF: 

Swine flu test developed here gets 'emergency' OK

News Outlet: 
The Huntsville Times
Date published: 
October 15, 2009

Technology checks many pathogens, speeds treatment

By Patricia McCarter
Times Staff Writer

Although it can take years for federal regulators to approve a new drug or medical test, the Food and Drug Administration has granted the Huntsville-produced Diatherix H1N1-09 influenza test "emergency use authorization."

HudsonAlpha investigator develops rapid response Swine Flu test

Diatherix Laboratories to make test available to physicians

Dr. Jian Han, faculty investigator at the HudsonAlpha Institute for Biotechnology, has completed development of a rapid response, molecular-level assay for swine flu, the current strain of the H1N1 family of the influenza virus. The test, which can confirm swine flu in less than six hours, will be incorporated into a viral respiratory panel made available by Diatherix Laboratories. The panel will detect the current strain of swine flu, as well as Influenza A, Influenza B and other viruses.

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