Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented at the annual meeting of the American Association for Cancer Research. The findings from St. Jude Children’s Research Hospital are expected to have an immediate and potentially life-saving impact on the growing population of childhood cancer survivors.
The study, called the St. Jude LIFE project is a collaboration between St. Jude and HudsonAlpha. Cancer survivors enrolled in St. Jude LIFE underwent whole genome and whole exome sequencing during 2015-16. St. Jude LIFE has enrolled more than 4,200 long-term survivors and aims to improve life for childhood cancer survivors now and in the future. Participants return to St. Jude periodically for several days of clinical and functional assessments.
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