HudsonAlpha internationally-renowned faculty members are committed to making impactful discoveries in genomics and genetics that improve health and create a more sustainable world.
Ph.D. in Biochemistry, University of California Berkeley
Genomic and genetic analysis of human traits and diseases.
Richard M. Myers, PhD, President and Science Director and M. A. Loya Chair in Genomics at the HudsonAlpha Institute for Biotechnology. The Myers lab focuses on applying functional genomics and genetics approaches to understanding how genes and regulatory regions contribute to basic biology, human disease, responses to the environment and population genetics.
Ph.D. in Biochemistry and Molecular Biology, Emory University
Epigenomic analysis of complex human traits and diseases
Devin Absher, PhD, uses the epigenome to study complex diseases and traits, especially autoimmune disease, cardiovascular disease, cancer and aging.
M.D. and Ph.D. in pathology, University of Washington, Seattle
Genetic architecture of morphologic variation
Greg Barsh, MD, PhD, Smith Family Chair in Genomics at the HudsonAlpha Institute for Biotechnology, studies the genetic mechanisms that underlie differences in individual appearance and that could give new insight into both basic biology and human disease.
MD, George Washington University School of Medicine
Human clinical genetics
David Bick, MD, is a clinical geneticist with more than 20 years experience diagnosing and treating children with genetic disorders. Bick is the medical director of the Clinic for Genomic Medicine on the HudsonAlpha campus.
PhD in Plant Breeding, Genetics, & Genomics, University of Georgia
Using genomics for crop improvement
Josh Clevenger, PhD, focuses on using genomics for crop improvement, especially crops in the southeast and Alabama.
Ph.D. in Genetics, Stanford University
Human Genetics and Genomics
Greg Cooper, PhD, researches the structures, functions and evolutionary histories of human genomes, with an emphasis on applying genomic approaches to study human disease.
Ph.D. in Genetics, Stanford University
Sara Cooper, PhD, focuses on combining metabolomics with genomics and applying that data to pancreatic and ovarian cancer.
Ph.D. in Microbiology, University of Leeds, United Kingdom
Genomic resource development for plants
Jane Grimwood, PhD, co-directs the Genome Sequencing Center at HudsonAlpha, managing one of the few centers in the world that produces, analyzes and interprets genomic data on economically important plant and organism species to improve crop breeding and other agricultural practices.
M.D., SuZhou Medical College, China; Ph.D. University of Alabama at Birmingham
Technology development to advance medical science
Jian Han, MD, PhD, focuses on developing integrated solutions for molecular differential diagnosis and mapping the personalized immunorepertoire.
PhD in Plant Biology, University of Georgia
Plant Reproductive, Evolutionary, and Comparative Genomics
Alex Harkess , PhD studies plant reproductive, evolutionary, and comparative genomics. His research has focused on the evolution and function of small RNA pathways, the evolution of sex chromosomes in plants, and broad-scale comparative genomics.
Ph.D. in Genetics and Molecular Biology, Emory University
Educational outreach relating to genetics, genomics and biotechnology
Neil Lamb, PhD, oversees all educational programming developed at HudsonAlpha as vice president for educational outreach. Lamb creates innovative teacher training, student experiences, public enrichment, classroom kits and digital resources that re-shape how science education is delivered.
Ph.D. in Biochemistry, Emory University
Technology development and automation, informatics, genomic variation
Shawn Levy, PhD, uses high performance genotyping and sequencing technologies to support projects from plant and animal phylogenetic studies to translational and clinical based projects at the Genomic Services Laboratory and the Clinical Services Laboratory.
PhD in medical genetics, University of Alabama at Birmingham
Promoting high quality and appropriate clinical genomic testing
Elaine Lyon, PhD, FACMG, uses high performance genotyping and sequencing technologies to empower the use of molecular genomics in a clinical setting to diagnose inherited diseases or predict susceptibility to disease through the Clinical Services Laboratory.
B.S. in computer science, B.S. in biology, North Central College
Whole genome sequencing and assembly, population genomics
Jeremy Schmutz co-directs the Genome Sequencing Center at HudsonAlpha, managing one of the few centers in the world that produces, analyzes and interprets genomic data on economically important plant and organism species to improve crop breeding and other agricultural practices.
PhD in Biology, Dartmouth College
Understanding the role of the rhizome in resource reallocation and perenniality.
Kankshita Swaminathan, PhD, studies the role of the rhizome in nutrient storage and reproduction in plants. She is interested in how perennial plants remobilize nutrients year after year.
Research Faculty Investigators
PhD in Philosophy, Bowling Green State University
How genetics can address adoptees’ lack of family health history
Thomas May, PhD, is interested in the intersection of medicine; public health; and moral, social and political philosophy, with a special interest in autonomy and healthcare.
PhD, University of North Carolina at Chapel Hill
Genetic and epigenetic regulation of neuronal function and the role of gene regulation mechanisms in cognitive and neuropsychiatric disease states
Jeremy Day, PhD, is an assistant professor in the Department of Neurobiology at the University of Alabama at Birmingham. Day received his PhD from the University of North Carolina at Chapel Hill in 2009 and completed a postdoctoral fellowship at UAB in the Department of Neurobiology. He joined the neurobiology faculty at UAB in 2014, where his lab investigates the neurobiology of reward-related memory systems in the brain and the role of these circuits in drug addiction. His research integrates molecular, physiological, behavioral, genetic and epigenetic tools to understand how experience alters the brain and how those changes drive future behaviors. Currently his lab is harnessing whole genome sequencing technology and genome editing tools to define how epigenetic and genetic mechanisms contribute to brain pathology in animal models of addiction. The ultimate goal of this work is to manipulate epigenetic or transcriptional patterns within selected brain regions to achieve therapeutic outcomes for brain diseases. Research in his laboratory is supported by grants from the National Institute on Drug Abuse, the National Institute of Mental Health, and support from the Civitan International Research Center and the UAB Pittman Scholar program.
MBBS, Christian Medical College, Vellore, India; Ph.D. Rockefeller University
Genomic instability in cancer cells and the role of noncoding RNAs in differentiation and cancer
Anindya Dutta, PhD, MBBS, is currently the Chair of Biochemistry and Molecular Genetics at the University of Virginia, and is the incoming Chair of the Department of Genetics at the University of Alabama at Birmingham School of Medicine. Dutta received his Bachelor of Medicine-Bachelor of Surgery (MBBS) from Christian Medical College, Vellore in India, and his Ph.D. from Rockefeller University in New York. He completed a residency in medicine at Christian Medical College Hospital in India, a postdoctoral fellowship at Cold Spring Harbor Laboratory supported by the American Cancer Society, and a residency in pathology at Brigham and Women’s Hospital in Boston, Massachusetts. His laboratory identified many of the replication initiation proteins in human cells, used genomics technology to identify hundreds of origins of replication in human chromosomes, discovered a major mechanism by which human cells prevent over-replication of their DNA, and identified a novel class of circular DNA present in normal mammalian cells. His laboratory is currently working on long noncoding RNAs that regulate cancer progression and a novel family of short regulatory RNAs called tRFs. He has served as Editor for Journal of Biological Chemistry and Associate Editor for Cancer Research. He has trained over thirty-five scientists who continue research in academia or industry and has received the following honors: Elected Fellow of the AAAS, Ranbaxy Award for studies on genome instability and the Outstanding Investigator Award of the American Society for Investigative Pathology.
Clinical genetics, syndrome delineation, dysmorphology and advancing technologies, phenotype integration in genomic sequencing, care coordination for children with complex medical needs
Anna C.E. Hurst, MD, MS, is an assistant professor of medical genetics in the department of genetics at the University of Alabama at Birmingham. She trained as a genetic counselor at the University of South Carolina School of Medicine (Columbia) and then completed her medical degree at the Medical University of South Carolina (Charleston). She is a board-certified pediatrician who completed pediatrics residency at Wake Forest Baptist Health (Winston-Salem, NC) and a medical genetics residency at UAB. Hurst is a clinician for the UAB Undiagnosed Disease Program, skeletal dysplasia clinic, and general genetics, and she provides genetic inpatient hospital consultations for patients at UAB and Children’s of Alabama. Her clinical interests include dysmorphology and congenital anomaly syndrome delineation, and she serves on the Scientific Advisory Board for Facial Dysmorphology Novel Analysis (FDNA). Her research focuses on expanding the availability of genomic sequencing for children with complex healthcare needs and incorporating phenotypic information into the interpretation of genomic data.
PhD in Molecular and Cellular Biology, University of Minnesota
Function of regulatory regions of genome in human genome and human genetic diseases
The Mendenhall lab works to define the function of the regulatory or non-coding regions of the genome. These regions control how genes are turned on or off in the appropriate cells of our bodies. The lab focuses on developing methods to define what determines a functional regulatory region, investigating how the DNA sequence establishes these regions and understanding how variation in human DNA can alter this regulation to produce human traits and human genetic diseases. This requires the lab to develop and use specific synthetic biology tools, including customizable DNA binding proteins (TALEs and Crispr/Cas), synthetic DNA libraries and next-generation sequencing to assign biological functions to non-coding regions of the genome.
MD, Cornell University and PhD in Genetics and Cell Biology, Rockefeller University
Genetics and treatment of neurofibromatosis type 1; Genetics and genomics education; Integration of genetics into medical practice
Bruce Korf, MD, PhD, completed his undergraduate studies and MD at Cornell University and received his PhD in genetics and cell biology from Rockefeller University. He then did training in pediatrics, child neurology and genetics at Children’s Hospital, Boston, and is board certified in all three areas, as well as clinical cytogenetics and clinical molecular genetics. He served as clinical director and associate chief of the Children’s Hospital, Boston Division of Genetics until 1999, when he assumed the role of medical director of the Harvard-Partners Center for Genetics and Genomics. In 2003 he moved to University of Alabama at Birmingham, where he is the Wayne H. and Sara Crews Finley Chair in Medical Genetics, and director of the Heflin Center for Genomic Sciences. From 2003 to 2017 he served as chair of the department of genetics and in 2017 he became chief genomics officer of UAB Medicine. He also is co-director of the UAB-HudsonAlpha Center for Genomic Medicine. Korf is past president of the Association of Professors of Human and Medical Genetics and of the American College of Medical Genetics and Genomics and currently is president of the ACMG Foundation for Genetic and Genomic Medicine. He has served on the Liaison Committee on Medical Education and the Board of Scientific Counselors of the National Cancer Institute and of the National Human Genome Research Institute at the NIH. Korf is author of Human Genetics and Genomics, co-author of Medical Genetics at a Glance, and co-editor of Current Protocols in Human Genetics and Emery and Rimoin’s Principles and Practice of Medical Genetics. His research focus is the genetics and treatment of neurofibromatosis type 1, and he also has a major interest in genetics and genomics education and the integration of genetics into medical practice.
MD, University of Ibadan, Nigeria; PhD, Biological Sciences in Public Health, Harvard University
Cancer Genomics, Infection-related cancers; Women’s cancers; Biomarkers for early detection of cancers and disease progression
In the Ojesina Lab, we seek to answer two big questions: (i) what are the genomic events that facilitate the progression of pre-malignant states to cancer, (ii) how do infections synergize with genomic alterations to cause cancer? Our work lies at the nexus of translational genomics, integrative molecular epidemiology, oncology, infectious disease, and global health, with a primary focus on infection-related cancers (including HIV-associated malignancies) and women’s cancers. We integrate high throughput sequencing with functional experiments in primary tissues and cell lines to investigate the mechanisms by which infections synergize with genomic and transcriptomic alterations to facilitate the tumor initiation, progression, response to therapy, recurrence and patient prognosis. We anticipate that this work will have translational impact by facilitating the development of diagnostic biomarkers and predictive models for early detection, prevention and treatment of various cancers, in local and global contexts.
PhD in Genetics and Genomics, Cornell University
Comparative, functional and evolutionary genomics in human and animals
The Wang Lab investigates the genetic and epigenetic regulation of gene expression in vertebrates and insects with a focus on allelic imbalance (AI). Diploid organisms inherit one set of haploid genome from the mother and one from the father, so relative equal mRNA expression of the two parental alleles is expected and observed for most genes in the genome. However, a subset of genes are expressed preferentially from one allele, and this deviation from 50%:50% in mRNA abundance is called allelic imbalance. Alterations of allelic imbalance are often associated with human and animal diseases including cancer, imprinting syndromes, aging and hypertensive disorders during pregnancy such as pre-eclampsia. The Wang Lab is working on general and extreme forms of allelic imbalance, including AI caused by cis- and trans-regulation of gene expression, genomic imprinting and X chromosome inactivation, through the profile of allele-specific expression (ASE), allele-specific DNA methylation (ASM) and allele-specific histone modifications. The goal is to understand the origin, evolution and mechanism of allelic imbalance and predict how aberrant AI pattern is associated with disorders in human and other animals. In collaboration with Ruth Ley, PhD, of Cornell University, Wang compared the gut metagenomes of anxiety patients and their normal identical twin from the TwinsUK project and identified differences in species composition/abundance and biological functional pathways. The Wang Lab is also interested in comparative analyses of gut metagenomes, meta-transcriptomes and meta-methylomes in human and animal diseases. Visit the lab website: http://vetmed.auburn.edu/faculty/xu_wang/
PhD in Cell Biology, University of British Columbia, Canada
Molecular mechanisms of sarcomagenesis.
Le Su, PhD, has been actively involved in sarcoma research for nearly ten years. As a junior fellow at HudsonAlpha, his major focus is on chromosomal translocation-associated sarcomagenesis in children and young adults.