HudsonAlpha faculty investigator contributes to coronary artery disease research

Study results published in Nature Genetics

HudsonAlpha Institute for Biotechnology’s Devin Absher, PhD, contributed to genotyping and analysis for a coronary artery disease (CAD) project led by the University of Cambridge that identified 15 new risk loci for CAD. The results of the study were published online this month in Nature Genetics.

The group of researchers used genome-wide association studies to develop a targeted gene array. Then they performed genotyping for more than 56,000 participants and added those data to nearly 195,000 previously genotyped individuals. The resulting analysis revealed 25 new SNPs associated with coronary artery disease. These SNPs are located in 15 genomic regions and are in or near genes involved in arterial-wall-specific mechanisms.