04 Dec 2018

HudsonAlpha Foundation’s M&M Program funds dementia research leading to discovery

Researchers identify new candidate genetic risk factor for type of dementia

Huntsville, Ala. – Scientists from the Myers Lab at the HudsonAlpha Institute for Biotechnology contributed to finding a newly-identified risk factor for one of the more common forms of early-onset dementia. The finding will help researchers by narrowing the focus for potential diagnostics and one day even treatments.

The researchers found that variation in the MFSD8 gene associates with a greater risk of developing frontotemporal lobar degeneration (FTLD), a disease that often has an early age of onset, and which can include difficult-to-manage symptoms, ranging from inappropriate social behaviors to speech problems.

The data collected in this new research, which was recently published in the scientific journal Acta Neuropathologica, suggests that rare MFSD8 variants make it harder for cells to dispose of their waste, which may lead to a toxic buildup of aggregated proteins associated with FTLD.

“We deeply value all contributions we can make to the understanding of dementia,” said Richard M. Myers, PhD, a HudsonAlpha faculty investigator. “The scientific community is making strides in understanding the genetic underpinnings of a number of neurodegenerative disorders.”

The University of California, San Francisco (UCSF) was the driving force behind the research, while scientists at the Albert Einstein College of Medicine also significantly contributed. HudsonAlpha assisted with the computational efforts as part of the Institute’s first work with the Memory and Mobility Program.

“Identifying the risk factors that accompany rare and early-onset forms of dementia gives us a better chance to understand neurodegenerative disorders as a whole,” noted Nick Cochran, PhD, a postdoctoral fellow in the Myers Lab. “With early-onset cases, we can more successfully isolate the genetic factors that go along with a variety of symptoms, which helps us build our knowledge base for the entire field.”

Bruce Miller, MD, director of the UCSF Memory and Aging Center, said, “Our continuing efforts to identify the genetic determinants of neurodegeneration will open new doors for predicting, diagnosing and treating these diseases. We are constantly adding to that knowledge bank, and this work is expedited by our collaboration with partners such as HudsonAlpha.”

Primary support for this study was provided by the Rainwater Charitable Foundation. Additional support was provided by the Memory and Mobility Program through the HudsonAlpha Foundation.