Two more researchers from the HudsonAlpha Institute for Biotechnology showcased their research in San Diego on Thursday at the 2018 American Society of Human Genetics annual meeting.
Andrew Hardigan of the Myers Lab presented a poster on the systematic dissection of transcription factor co-binding as a positive predictor of regulatory activity. By combining ENCODE ChIP-seq data with machine learning and subsequent high-throughput reporter-assay validation, this project analyzed the quantitative relationship between transcription factor co-binding and gene regulatory activity and lends support to the important regulatory role of transcription factor high-occupancy target (HOT) regions in the genome.
Megan Breitbach brought research from the Absher Lab to the conference, displaying a poster on exonic variants in aging-related genes, demonstrating that they are predictive of biological aging status. The poster walked through the research, which aimed to identify genetic variants linked to accelerated or delayed biological aging. The study found that more complex statistical analyses may help interpret the large sets of rare data involved.
Thursday’s presentations from HudsonAlpha scientists follow a day of robust contribution to the conference that included a number of other research posters along with a presentation and participation in a panel discussion on spreading genomic literacy to a broad audience.
