Deeann Wallis, PhD., Associate Professor in the Department of Genetics at UAB, received a grant entitled “Functional significance of VUS in Ras pathway genes: NTRK2, 14-3-3 zeta, BRAF, and EGFR and potential therapeutics” They propose to express wild type (WT) or mutant cDNAs in HEK293 cells and evaluate downstream molecular phenotypes both with and without therapeutics. They propose to focus specifically on the Ras pathway during the pilot project. However, assuming success, the aim is to expand to other cell types, assays (cell death/proliferation), and signaling pathways (beyond Ras) to include a broader area of therapeutic development based on variants found through sequencing.

The research group comprises Dr. Wallis, four faculty and one postdoctoral fellow at UAB.