Friday at ASHG: HudsonAlpha’s Brittany Lasseigne presents poster
Brittany Lasseigne, PhD, a postdoc at HudsonAlpha Institute for Biotechnology, presented her poster, “Genomic instability phenotypes in multidimensional genomic cancer studies,” at the American Society of Human Genetics annual meeting in Orlando, Fla.
The ability to infer molecular signatures from various genomic data sets can aid in prioritizing future experiments and provide biological insight into disease-associated pathways and mechanisms.
For this study, Lasseigne studied chromosomal instability and DNA methylation instability in kidney cancer, characterizing their relationships to each other and to clinical phenotypes (i.e. patient survival).
The results suggest those metrics are capturing distinct biological properties to a considerable extent. Chromosomal instability better predicted long-term surviving patients, while DNA methylation instability better predicted non-surviving patients.
Lasseigne stated, “Our findings will facilitate prioritization of experiments in future studies, improve interpretation of these instability signatures for both basic biology and clinical use, and allow their inference from each of the major genomic data types.”