The National Institute of Mental Health has awarded the HudsonAlpha Institute for Biotechnology and the University of Michigan grant monies totaling $7.8 million to identify genes and pathways that contribute to the risk for bipolar disorder.
By Andrea Anderson
Using an approach called reduced representation bisulfite sequencing to simultaneously gauge genome-wide DNA methylation and sequence patterns in three generations of family members, researchers have found evidence that genotype has a more widespread influence on DNA methylation patterns than previously appreciated.
Study promotes improved diagnostics for severe pediatric disease
HUNTSVILLE, Ala - A study of almost 16,000 children with intellectual disability and various congenital defects is providing insight to more precise connections to anomalies in the genome. Greg Cooper, Ph.D., a faculty investigator at the HudsonAlpha Institute for Biotechnology, together with colleagues at the University of Washington in Seattle, and a dozen other organizations, identified 59 potentially pathogenic copy number variants and associated genes that appear to be linked to such disorders. The paper is currently available in the online version of Nature Genetics.
HudsonAlpha researchers demonstrate sporadic mutations may be responsible for half of schizophrenia cases
HUNTSVILLE, Ala. - Although it affects less than 1 percent of the global population, schizophrenia exacts a large toll in terms of expense and human suffering. A new study from researchers at the HudsonAlpha Institute for Biotechnology, with colleagues from Columbia University in New York and the University of Pretoria in South Africa, indicate non-familial genetic mutations may account for about half of schizophrenia cases.