Please join us for our next seminar Wednesday, November 9 at 12pm in the HudsonAlpha auditorium featuring David C. Williams, Jr., MD, PhD.

Williams is an associate professor in the department of pathology and laboratory medicine at the University of North Carolina Chapel Hill. A board certified anatomical pathologist with specialty in hematology, Williams uses structural and biophysical techniques to probe protein-protein and protein-DNA interactions critical to the formation of macromolecular complexes. Over the past several years, he has been studying the Nucleosome Remodeling and Deacetylase (NuRD) complex responsible for recognizing methylated DNA and silencing expression of the associated genes. His focus has been to understand how a key component of this complex, the methyl-cytosine binding domain protein 2 (MBD2), binds DNA and recruits the rest of NuRD. Utilizing biophysical techniques such as NMR, ITC, FP, molecular dynamics simulations, and tight roping assays, Williams has developed one of the most well understood biophysical models for MBD recognition of DNA methylation and recruitment of the NuRD complex. His work has also elucidated the evolutionary aspects of DNA methylation recognition in species down into sponges.

Jeremy Prokop, PhD, will host Wednesday’s seminar.

More information on HudsonAlpha Research Seminars can be found at hudsonalpha.org/seminars.

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