Using whole genome sequencing, a team of researchers, including CSL and GSL Director Dr. Shawn Levy have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.

The investigators say their study is one of the first of rare genetic variations in people with bipolar disorder, which, in contrast to most previous studies of common variation, can provide a more direct insight into the biology underlying the susceptibility to bipolar disorder.

And the report on the work published on June 1 in JAMA Psychiatry, led by Fernando Goes, M.D., assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine, affirms the need for DNA from a vast patient population to definitively confirm the role of rare mutations identified using the most advanced genome sequencing techniques.

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