Investigator Positions

Evolutionary Bioinformatics Intern

Investigator: Greg Barsh, MD, PhD

Education Level: Undergraduate student

Hours per week: 30

Description: The intern will work on the bioinformatic annotation and analysis of mammalian genome sequence and transcriptome data from unconventional (non-model) organisms.

See http://genome.cshlp.org/content/21/11/1905.full or http://www.sciencemag.org/content/337/6101/1536.short for an example.

 

This is a heavily computer-based position that requires initiative, independence and critical thinking.

Requirements:

  • Working knowledge of command line interface and scripting language(s) such as Perl or Python
  • Familiarity with basic biological and genetic principles
  • Strong background in and experience with computing
  • Interest in evolution, biology and natural variation

Computational Research Intern in Genomic Sciences

Investigator: Greg Cooper, PhD

Education Level: Undergraduate or Masters Level Graduate student

Hours per week: 30

Description: This computational internship position requires an upper-level undergraduate or Master’s level student. The opportunity will involve programming to support a clinical genetics research project. Particular focus will be given to the development of computational tools to track and manage analyses. Applicants should have a strong interest in both computation and biology.

Requirements:

  • Fluency in multiple computational environments, especially OS X and command line interfaces with UNIX-like operating systems
  • Experience with one or more scripting languages like Perl, Python or others
  • Comfort manipulating large text files and datasets from diverse information sources
  • Strong communication skills and a readiness to work with others
  • Interests in human genetics and genomics and familiarity with relevant, basic biological concepts

Genome Engineering Internship

Investigator: Eric Mendenhall, PhD

Education Level: Undergraduate or Masters Level Graduate student

Hours per week: 30

Description: The Mendenhall Lab is using the Crispr/Cas9 method of genome engineering to determine the consequence of DNA sequence variation in humans. We are seeking an enthusiastic individual to assist with the design and cloning of DNA vectors and cell culture models of human phenotypes. This position is suited for biology, chemistry or engineering majors, and requires independence, organization and critical thinking.

Requirements:

  • Experience in common laboratory techniques or computer programming a plus, but not necessary
  • Highly motivated student who will take advantage of the opportunity

Genomics Laboratory Assistant

Investigator: Richard Myers, PhD

Education Level: Undergraduate or Masters Level Graduate student

Hours per week: 30

Description: Interns will be immersed in a leading genomics laboratory working on a variety of projects relating to human disease and transcriptional regulation. The Myers Lab uses genomics approaches to better understand and classify human disease focusing on undiagnosed pediatric disorders, ALS, breast, pancreatic and kidney cancer. Interns can expect to learn a variety of techniques, both on the lab bench and computational, related to using genomics and genetics to study human biology and disease.

Number of positions expected: 1 or 2

Requirements:

The most important requirement is a motivated student who will take advantage of the opportunity, as there are so few positions available for the number of applicants. While the student does not have to be certain that he/she wants to go to graduate school to become a scientist, we are definitely interested in those undergrads and masters students who are considering science as a career. (We’ll consider beginners as well as those who already have some lab experience.) Interest and experience in computation in a terminal environment is helpful, though not necessary.

Going Beyond the Diagnosis Internship

Investigator: Liz Worthey, PhD

Education Level: Undergraduate or Masters Level Graduate student

Hours per week: 30

Description: Currently in many rare disease cases, even where we have obtained a molecular diagnosis, we remain unable to predict the expected severity and path of the disease phenotype. This leaves patients and their families in limbo waiting to see how the particular course of disease will present in them or their family members.

Through in depth analyses taking into account both the nature of the change and how it may affect both the structure and function of the resulting protein and its interactions with other cellular components as well as integration of existing genotype – phenotype datasets, we believe that we can do a much better job of providing clinically useful phenotype predictions. 
This position will use a variety of methods to study this approach in a number of patients where useful data already exists. The goal is to determine whether in these and other cases we can go beyond the diagnosis and find information to share about the potential path of an individual patient’s disease.

Requirements: No programming experience necessary, but general computer skills (Microsoft Office and Google apps) are a must. Background in general biology, genomics and statistics preferred. Applicant must have a strong desire to work on clinical analysis of whole genome sequence data and the ability to work at a computer monitor for significant portions of the day.

Variant of Uncertain Significance (VUS) Characterization Intern

Investigator: Howard Jacob, PhD; Jozeph Lazar, MD, PhD

Education Level: Undergraduate or Masters level graduate student

Hours per week: 30

Description: The Lab of Howard Jacob focuses on human whole genome sequencing studies for rare and cardiovascular diseases, characterizing variants that are discovered with these approaches. With many variants of ambiguous causality, known as Variants of Uncertain Significance (VUS), these variants must be tested for impact to normal biology. This internship will provide an opportunity to work with one or two of these VUS discovered from patients. Variants will be introduced into various expression vectors or cell lines through CRISPR/Cas9 followed by molecular and biochemical characterization. The internship will provide experience in protein modeling, molecular dynamic simulations of proteins, protein purification, protein-protein interaction assays, cell culture, and cellular functional assays depending on the disease of interest.

Requirements:

Basic experience with cell culture or protein purification is useful, but not required. 

Plant Genomics Intern

Investigator: Kankshita Swaminathan, PhD

Education Level: Undergraduate or Masters level graduate student

Hours per week: 30

Description: The Swaminathan lab uses functional genomics, molecular biology and bioinformatics to understand traits of importance for sustainable energy production. The intern will have the opportunity to learn molecular biology techniques as well as some basic genomic data analysis. The work will focus on C4 bioenergy grasses and may include some sample collection in the field, sample processing, data analysis, and testing hypotheses from the data analysis in a wet lab.

Requirements:

An interest in plant biology, but no prior experience in it, is essential. The student must also be highly motivated and interested in a career in biology. We will consider undergraduates who have chosen biology as their major, as well as life science masters students. It is important that the intern is meticulous in their note taking, capable of working independently, and is a good team player. Since we do collect samples in the field, there must be a willingness to work outdoors.

Genetic Counseling Intern

Investigator: Neil Lamb, PhD

Education Level: Undergraduate or Masters level graduate student

Hours per week: 20

Description: This position will work closely with the genetic counseling team at HudsonAlpha. Activities will include developing and implementing educational resources and programs for healthcare audiences and providing support for the genetic counseling aspects of projects at HudsonAlpha and the Smith Family Clinic for Genomic Medicine, LLC. The selected student will gain hands-on experience communicating complex genomic information in person, over the phone and in writing. The ideal candidate for this internship is an undergraduate or graduate student interested in pursuing a career as a genetic counselor.

Requirements: 

Applicants should have the following:

  • Ability to work independently as well as in a team
  • Ability to communicate in a professional and clear manner
  • Strong attention to detail
  • Foundational understanding of genetics and genomics concepts
  • Documentation of Hepatitis B vaccination and negative Tuberculosis skin test (or willingness to complete prior to start of internship)
  • Willingness to comply with Institute and Clinic policies and procedures

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